High quality of Buy 25086-89-9 Copovidone in stock CAS NO.25086-89-9

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ProName: High quality of Buy 25086-89-9 Copovi...
CasNo: 25086-89-9
Molecular Formula: （C6H9NO）n+（C4H6O2）m
Appearance: White or off white powder
Application: Pharmaceutical & Health Care
DeliveryTime: 15-20days
PackAge: net 20kg fibre drum
ProductionCapacity: 200 Metric Ton/Month
Purity: 95%
Transportation: By sea or by air
LimitNum: 0 Metric Ton

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Buy High quality of 25086-89-9 Copovidone in stock

CAS: 25086-89-9

MF: C30H45N3O9X2

MW: 591.69

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Product Categories: Hydrophobic Polymers;Materials Science;Hair Care;Polymer Science;Vinylpyridine and Vinypyrrolidone Polymers;API;Polymers;Hydrophobic Polymers;Poly(vinylpyrrolidone);Vinylpyridine and Vinypyrrolidone Polymers

Mol File: 25086-89-9.mol

Poly(1-vinylpyrrolidone-co-vinyl acetate) Structure

Poly(1-vinylpyrrolidone-co-vinyl acetate) Chemical Properties

density 1.27 g/mL at 25 °C(lit.)

refractive index 1.4300 to 1.4380

Fp 72 °F

solubility Greater than 10% solubility in 1,4-butanediol, glycerol, butanol, chloroform, dichloromethane, ethanol (95%), glycerol, methanol, polyethylene glycol 400, propan-2-ol, propanol, propylene glycol, and water. Less than 1% solubility in cyclohexane, diethyl ether, liquid paraffin, and pentane.

form powder

Stability: Stable. Combustible, especially in powdered form. Incompatible with strong oxidising agents, strong reducing agents.

EPA Substance Registry System Vinyl acetate N-vinyl-pyrrolidone polymer (25086-89-9)KoVidone VA64 possesses excellent powder and film properties for broad application in the pharmaceutical field.

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THE COMPANY

• Publicly traded company on the Shenzhen stock exchange (stock code 300109)

• First domestic company to develop and manufacture PVP and PVM/MA products

• 3rd Largest Global PVP manufacturer

• 2nd Largest Global PVM/MA manufacturer

• International subsidiaries in China,Europe and Japan

• Global distribution network

OUR PRODUCTS

• KoVidone® and PolyKoVidone® line of products representing Povidone, Crospovidone and Copovidone pharmaceutical excipients.

• OraRez® line of PVM/MA copolymer and derivatives representing functional polymers for bioadhesive/mucoadhesive applications.

• KoVidone®-I (PVP-I) broad spectrum biocidal, antifungal and antiviral agent.

• Pharmaceutical solvents and intermediates.

QUALITY

• First Chinese manufacturer to be EXCiPACTTM GMP certified

• All pharmaceutical products manufactured under strict cGMP guidelines

• All pharma products handled and packaged in class D cleanrooms

• State of the art manufacturing facility (commissioned 2013)

• QC equipment and test methods fully validated and fully audit trail compliant

ENVIRONMENTAL RESPONSIBILITY

• Fully compliant with government requirements and regulations

• Real time monitoring of waste streams

• 100% recycling of processing water

• Complete conversion from coal to natural gas

• Focus on developing green production processes

　　CUSTOMER and TECHNICAL SERVICE

• Technical Research Center to assist our customer with formulation development

• New R&D center commissioned in 2018 having integrated R&D and pilot manufacturing

• Customer partnering to develop new opportunities

• Strong customer and quality management services to assist our customers

KoVidone® VA64

Product name KoVidone® VA64 Copovidone

USP/EP name Copovidone, Copovidonum

INCI/CTFA VP/VA copolymer 60/40

CAS NO. 25086-89-9

K value 25.2-30.8 (Copovidone 28), 27.0-33.0 (Copovidone 30)

Properties Hygroscopic capacity lower than KoVidone® K30; Soluble in water, alcohol and many other organic solvents; Glass transition temperature(Tg) lower than KoVidone® K30; Forms transparent, water removable films.

The content of vinyl acetate 35.3-41.0%

Applications

KoVidone® VA64 possesses excellent powder and film properties for broad application in the pharmaceutical field:

· Water soluble tablet binder; suitable for wet or dry granulation and direct compression processes, improves particle compressibility.

· Film-former; permeable film coating for tablet and sugar coatings to protect against splitting, decrease moisture sensitivity and provide good film adhesiveness, elasticity, and hardness.

· Porogenic agent; for use in taste-masking and component of the matrix material used in controlled-release formulation.

· Solubilizing agents; for solid dispersion processes to enhancing bioavailability and improve drug solubility. For use in both Hot Melt Extrusion and Spray Solvent Drying

The addition of KoVidone® VA64 to HPMC film coating solutions can effectively reduce the viscosity of the HPMC solution while enhancing resultant film characteristics by improving film formation, flexibility and gloss.

Nimodipine- KoVidone® VA64 solid dispersion HME process

Due to its lower glass transition temperature Tg, KoVidone® VA64 is especially suited for developing solid dispersion drug systems via hot melt extrusion processing.

Hot melt extrusion (HME) technology is a new technique to prepare pharmaceutical dosage forms. HME shows unique advantages and is used to: improve the dissolution rate of extremely poorly soluble drugs..

HME uses no solvent in the production process, the drug is hot melt extruded with a suitable polymer carrier (Kovidone® VA64). The extrusion process converts crystalline drugs to their amorphous form (Solid Dispersion) that helps to improve both drug solubility and bioavailability and increase the stability of the finished dosage form.

Solid Dispersions can also be produced via Spray Solvent Drying whereby the Kovidone and poory soluble active are dissolved in a suitable solvent and spray dried. The resulting Solid Dispersion is similar to that achieved with HME.

High quality of Buy 25086-89-9 Copovidone in stock CAS NO.25086-89-9

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